for short procedures. In orally premedicated patients we obtained midazolam plasma concentrations at the end of\nsurgical procedures and compared those to concentrations at anesthesia induction.\nMethods: The study was conducted prospectively with consent of the local ethics committee (Ethikkomission\nKanton Thurgau, Switzerland) and carried out with written informed consent of each patient. Female patients aged\n20 to 60 years undergoing elective procedures with general anesthesia were included, and were divided in two\ngroups according to the planned surgical time: group S (<30 min) and group L (90ââ?¬â??120 min), respectively. All patients\nreceived 7.5 mg Midazolam po as premedication. Blood samples were drawn at anesthesia induction, and at the end\nof surgery. Data were compared with t-test (independent samples; significance level p <0.05).\nResults: Twenty-five patients per group were included. Four patients were excluded from analysis, since midazolam\nwas not detectable in any samples. Time of premedication to the 1st blood sample was not statistically different between\ngroups, neither were Midazolam plasma levels at this time point (p = 0.94). None of the patients from group L (n = 24),\nbut five patients in group S (n = 22) did have a higher plasma level of Midazolam at the end of the case compared to\nthe beginning.\nConclusions: The elimination half-life of oral Midazolam can lead to higher plasma levels at the end of a short\nprocedure compared to those at induction of anesthesia.
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